Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer

Inclusion criteria: This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive NSCLC that is stage IV or has not responded to previous RET directed therapy.

SWOG PATIENT MATERIALS HERE https://www.swog.org/patients/trials-open-patients/adding-drug-selpercatinib-usual-treatment-ret-positive-advanced-non

Sponsor/Collaborator: Southwest Oncology Group|National Cancer Institute (NCI)

Contact and Locations:
Principal Investigator: Yasir Y Elamin,SWOG Cancer Research Network
Locations: https://clinicaltrials.gov/study/NCT05364645#contacts-and-locations

Mechanism of action: Selpercatinib, also known as LOXO-292, is a highly selective and potent, oral inhibitor for the treatment of patients with cancers that harbor abnormalities in the RET kinase.

Phases: Phase 2

NCT Number: NCT05364645

Status: Recruiting

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