Miss the 2024 RET Research Update? Watch it here
Our mission: To save the lives of RET-positive lung cancer patients by advancing research and treatment options.
We fund and facilitate cancer research, and we educate and empower patients to participate in clinical trials and lung cancer registries.
Our mission: To save the lives of RET-positive lung cancer patients by advancing research and treatment options.
We fund and facilitate cancer research, and we educate and empower patients to participate in clinical trials and lung cancer registries.
Patient Education
Read blog posts and watch videos about RET cancer research, treatment options, resources, and more
Scientific research can be confusing and overwhelming
Receive emails about RET-positive research and what it means for current treatment options and future therapies.
Introducing Our New Video Q&A Series
Our Q&A videos help you make sense of the science, featuring questions from patients and caregivers answered by members of the scientific community.
When Abnormal Cells Multiply
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. This leads to abnormal activation of the cell membrane receptor, basically resulting in the “on-off” switch to get stuck in the “on” position and causing these abnormal cells to multiply and spread. RET alterations occur most commonly in lung cancer – specifically non-small cell lung cancer (NSCLC) – and approximately 37,500 people are diagnosed worldwide and 4,000 in the U.S. each year.
Currently, selpercatinib and pralsetinib are the two FDA-approved RET-inhibitors that selectively target the RET protein. While these treatments show great benefit in most patients, within 1-3 years many RET-positive lung cancer patients become resistant to the therapies and their cancer progresses again. Finding new therapies that prevent resistance and are effective long-term is critical.
Learn more about RET-positive NSCLC
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