A study testing a the anti-TROP2 antibody-drug conjugate sacituzumab tirumotecan (MK-2870) versus chemotherapy in previously treated non-small cell lung cancer (NSCLC) with genomic alterations including RET

Inclusion criteria: Metastatic non-squamous NSCLC with RET alterations. Documentation of locally assessed radiological disease progression while on or after last treatment.

Sponsor/Collaborator: Merck Sharp & Dohme LLC

Contact and Locations:
Study email: Trialsites@msd.com
Phone Number: 1-888-577-8839
Locations (U.S. and outside the U.S.): https://clinicaltrials.gov/study/NCT06074588#study-overview

Mechanism of action: Sacituzumab tirumotecan is an investigational trophoblast cell-surface antigen 2 (TROP2)-directed antibody drug conjugate (ADC).

Phases: Phase 3

NCT Number: NCT06074588

Status: Recruiting

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